ALIEN V PREDATOR V...

Oh good lord, as much as I love Dead Space ( I own each game, a shit ton of exclusive merchandise, and rant about it every day), I must say, Isaac couldn't stand up to a Predator. An Alien, maybe, at long range, but then there's the acidic blood factor to consider. On a dark ship full of blood, clutter, and dust, Isaac just would not be able to see a Predator in Camo. If Isaac had the Elite Advanced Suit, the Line Gun, or a Javelin Gun, the odds may tip in his favor, but it depends on environment and whether or not there are Necromorphs to distract the Predator.